منابع مشابه
Tugging and pulling in asymmetric cell divisions
Tugging and pulling in asymmetric cell divisions n asymmetric divisions, the cell alters the normal process that centers the spindle in the mother cell, but how it regulates the timing of spindle movement is unclear. Now, on page 245, Labbé et al. describe a tethering system that resists premature movement of the mitotic spindle during asymmetric cell divisions in C. elegans embryogenesis. It w...
متن کاملMechanical tugging force regulates the size of cell-cell junctions.
Actomyosin contractility affects cellular organization within tissues in part through the generation of mechanical forces at sites of cell-matrix and cell-cell contact. While increased mechanical loading at cell-matrix adhesions results in focal adhesion growth, whether forces drive changes in the size of cell-cell adhesions remains an open question. To investigate the responsiveness of adheren...
متن کاملGuiding cell migration through directed extension and stabilization of pseudopodia.
Cell migration requires establishment of a single pseudopodium in the direction of movement. Here we highlight recent advances in our understanding of the molecular signaling mechanisms that regulate formation of pseudopodia. We discuss how signal transduction processes are spatially and temporally organized to establish cell polarity through directed extension and stabilization of dominant pse...
متن کاملEndogenous electric fields as guiding cue for cell migration
This review covers two topics: (1) "membrane potential of low magnitude and related electric fields (bioelectricity)" and (2) "cell migration under the guiding cue of electric fields (EF)."Membrane potentials for this "bioelectricity" arise from the segregation of charges by special molecular machines (pumps, transporters, ion channels) situated within the plasma membrane of each cell type (inc...
متن کاملMeasuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors).
Cells generate traction forces upon adhesion to the extracellular matrix as well as to neighboring cells. These forces are important for the growth and maintenance of adhesion structures such as focal adhesions and adherens junctions, and may play roles in tissue development. Here, we describe a method for measuring the tugging force transmitted across the cell-cell junction between two paired ...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2013
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2013.06.003